STUDIES ON THE DISTRIBUTION OF N-ACETYL-l-ASPARTIC ACID IN BRAIN
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چکیده
منابع مشابه
The enzymatic synthesis of N-acetyl-L-aspartic acid by a water-insoluble preparation of a cat brain acetone powder.
An acetone powder of cat brain catalyzed the synthesis of two radioactive products when incubated with L-aspartate-14C and acetyl coenzyme A. The products were identified as Nacetyl-aspartic acid and citric acid. A water extract of the powder contained the system that produced citrate-14C, while the residue contained the aspartate N-acetyltransferase activity. The soluble system rather than the...
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The occurrence of N-acetyl+aspartic acid in mammalian and avian brain at concentrations from 80 to 120 mg per 100 g fresh weight of tissue was demonstrated recently by Tallan et al. (1). The pattern of distribution of acetylaspartic acid in bovine brain was found by Tallan (2) to parallel that of many enzymes and to correlate equally with both the distribution of respiratory activity and the de...
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Previous studies suggest that baseline differences in neuronal markers between patients with obsessive-compulsive disorder (OCD) and healthy controls no longer exist following successful pharmacotherapy. The current study used proton magnetic resonance spectroscopy (MRS) to investigate differences in absolute concentrations of neurochemicals (i.e., N-acetyl-l-aspartic; NAA) in the head of the c...
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Metabolism of L-aspartic acid.
Aspartic acid, like glutamic acid, occupies a central position in amino acid metabolism. In most tissues it takes part in the transamination reaction (1). In the liver and the kidney, where all amino acids undergo cleamination, the rate of this process for aspartic acid is second only to glutamic acid (2). For these reasons, one would expect the exchange of amino nitrogen of aspartic acid with ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1957
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)65008-2